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*********************************************** Save a fortune on Levitra; COMPARISON SHOP Internet pharmacies compete for your business to drive down prices. Click Here to Comparison Shop For Levitra ***********************************************
Buying Generic Levitra On The Internet
When you buy brand name Levitra on the internet expect to pay a lot more, about $10.00 per pill or more. Generic Levitra, can be obtained for as little as $2.00 per pill from countries with lax patent laws (such as India).
When you buy internet Levitra, there are lots of people trying to rip you off. For instance, you may order Levitra 5mg, but they sell you 20mg tablets broken in half. You get a little baggie of half-tablets and Levitra crumbs.
The best way to find a legitimate Levitra merchant is to go by word of mouth. Another technique is to visit the site and test out the customer service telephone number or customer service instant message chat.
Ask them a few questions such as: - "When I buy the Levitra, where is it shipped from" - "What is the expiration date?" - "How long have you been in business?" - "How long will it take for my pills to get here"
If they do not answer the customer service number, of they take too long to respond to your chat questions, go to a different site.
Levitra (Vardenafil) is a member of a family of drugs called PDE5 Inhibitors.
Levitra Dose, Levitra Cost:
Levitra is available in tablet form in the following strengths: 2.5mg, 5mg, 10mg and 20mg. Legitimate internet pharmacies like RxUsa.com or Drugstore.com charge $9.00 to $10.00 per Levitra 10mg pill (the usual starting dose) when you buy 30 pills.
Maximum Dose Of Levitra
The maximum dose of Levitra is one pill per day. The usual starting dose of Levitra is 10mg once per day (60 minutes prior to sexual activity). The dose can be titrated up to 20mg or down to 2.5mg based on efficacy and side effects. Levitra can be taken without regard to food.
How Does Levitra Work (Levitra Mechanism Of Action)
When an erection goes flaccid, you have PDE5 to thank. Specialized penis tissue secretes a substance called cyclic guanosine monophosphate (cGMP) in response to sexual stimulation. The more cGMP available, the more durable the erection. Levitra inhibits the PDE5 enzyme, preserving cGMP levels, therefore aiding erection viability and durability.
Levitra Pharmacokinetics; Absorption, Onset, Bioavailability:
Levitra is rapidly absorbed from the bloodstream. It is about 15% bioavailable. Levitra (vardenafil) is about 95% bound to plasma protein. Maximum plasma concentration of Levitra occurs between 30 minutes and 2 hours after you take the pill.
The Levitra label states that you should take a pill approximately 60 minutes before sexual activity.
Levitra Pharmacodymanics, Sise Effects, Metabolism
Levitra is mostly metabolized in the liver by an enzyme known as CYP3A4 and to a lesser extent CYPC2. Levitra breakdown products are excreted in the feces (91-95%) and in the urine (2-6%).
If you are going to take Levitra, it is very important that your doctor be aware if you have a liver condition (such as cirrhosis) because you may need a special dosage adjustment.
If you try to obtain Levitra on the internet, please make sure that the person authorizing your prescription knows the true status of your liver function.
Levitra Marketing:
When Levitra was launched, they tried to create a tough guy, macho image for Levitra, as if to say that "even big strong men experience difficulty getting and staying erect". The ads were very "in your face".
The Levitra marketers used Mike Ditka, a chubby, aging, macho, football player as a spokesman. They ran a promotion whereby you could visit the Levitra website and sign up to win tickets to the Superbowl (something that had never been done with a drug before).
However, the macho man campaign didn't work so well, so they dumped Ditka. Now they use a 40-something year old brunette woman who says something like : " Do you want to know little secret? Then she tells you all about how great Levitra is".
Now the Levitra advertisements focus on a more subtle effect. The Levitra advertisements and propotional materials use a candle as a metaphor for intimacy and passion.
The BIG Discovery
Some very smart scientists discovered that cyclic guanosine monophosphate (cGMP) was the key to sustaining an erection.
They discovered that when a man gets sexually stimulated, a chain reaction occurs in the tissue of the penis that results in elevated levels of a substance called cyclic guanosine monophosphate (cGMP).
As long as there are sufficient levels of cGMP, the penis can remain erect. The more cGMP, the more robust and durable the erection.
If you inhibit the degradation of cGMP it stays around in the penis longer, producing a more durable erection.
Another way you can think of Levitra (and all other similar medicines) is that it preserves the elevated levels of cGMP that are created when a man is sexually stimulated for a stronger, more lasting erection.
That's how Levitra works - Levitra blocks the enzyme phosphodiesterase-5 (PDE5) which is responsible for the neutralization of cGMP. Levitra (Vardenafil) is a highly selective inhibitor of PDE5. (PDE5 is not the only phosphodiesterase involved in the erectile physiology but it appears to be the most important one).
The nice thing about PDE5 blockers is that they shouldn't cause erections at inappropriate times because they only block degradation of cGMP produced in reaction to sexual stimulation, such as thinking about something sexy. If you are not being sexually stimulated, there is no cGMP to protect, so the drug remains in the background.
Levitra Information On The Internet:
Recent Scientific Trial Regarding Levitra (vardenafil) versus Cialis (tadalafil) & Viagra (Sildenafil) regarding effects on pulmonary smooth muscle tissue (in an animal model). Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets. … Sildenafil and tadalafil did not affect the phenylephrine-induced contractions, whereas vardenafil reduced the maximal responses … results indicate that vardenafil, in contrast to sildenafil or tadalafil, also blocked Ca(2+) fluxes, thus enhancing its vasorelaxation of the pulmonary artery …[ British Journal of Pharmacology (2008) 154, 787-796; doi:10.1038/bjp.2008.141; published online 21 April 2008]
Levitra Price Comparison: There is a lot of competition between sites that sell Levitra. This competition drives down the prices.
Our editors have searched the internet. Here are the top 10 internet websites that sell Levitra. You can get a real good deal on Levitra if you comparison shop See Also> Top 10 websites that sell Levitra
Levitra Versus Viagra From Forbes magazine 10/06/03; by M. Herper and A. Lagorce; Side by side comparison of various characteristics; cost, pharmacokinetics, spokesperson, marketing, etc.
Levitra.com Geared to patients; all about Levitra and erections, including an illustrated picture of how an erection works; also contains information on what to expect once you take the pill.
Official Levitra Prescribing Information (Package Insert); dose, mechanism of action, side effects, precautions, warnings; patient information; very technical, don't get scared when you come to the section on warnings and side effects. [ This information is provided as a PDF document. You will need Adobe Acrobat to view this information]
Levitra Patient Information Who should take Levitra, who should avoid Levitra, drug interactions, warnings, cautions, drug interactions.
Levitra Scientific Papers ( from the National Library of medicine) automated Medline search; a listing of scientific papers in abstract form regarding Levitra.
Levitra News (from Google) ; recently published news regarding Levitra.
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