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Internet Drug News'

Crestor (rosuvastatin calcium)
information for patients, pharmacists, pharmaceutical marketers; side effects, dose, cost, mechanism of action, warnings; Crestor is a member of the statin family (closely related to Lipitor). How does Crestor work; Crestor mechanism of action; compare Crestor prices.


Crestor Logo: Somewhat resembles an image of a person with their arms up as if to  symbolize  victory .

Crestor Information:

Crestor (rosuvastatin calcium) received final approval for use in the United States in August, 2003. 

Crestor is a member of a family of drugs known as "Statins".  Other members of the statin family include: Lipitor, Zocor, Pravachol, Lovastatin, Advicor. 

Crestor reduces your cholesterol by blocking the liver from manufacturing  cholesterol.  In humans, the liver creates cholesterol at night while you are sleeping.  For this reason, Crestor (as well as all of the other statins) should be taken at night.

Crestor is marketed by the AstraZeneca Corporation (a large British pharmaceutical company).

Important Background Information:

Think of your liver as a cholesterol factory.  Even if your diet was 100% fat-free, your body would still manufacture cholesterol because cholesterol is needed by your body to create certain hormones and cell membranes.

There are two types of cholesterol - LDL and HDL.  HDL cholesterol is good for you.  Doctors call HDL the "Good Cholesterol". 

Conversely, LDL is considered to be the "Bad Cholesterol".  High levels of LDL cholesterol are associated with diseases such as heart attack and stroke. Crestor's main job is to reduce LDL levels and increase HDL levels in your blood. 

As your LDL levels decrease and your HDL levels increase, your risk of  stroke and heart attack decrease.

How does Crestor work?  plagiarizexyz

Crestor works directly in the liver.  Crestor inhibits an enzyme that is present in the liver which is necessary to manufacture the bad cholesterol (LDL). 

By inhibiting or blocking the action of this liver enzyme, your body's ability to produce cholesterol is dramatically reduced.  As an added benefit, Crestor elevates HDL levels.

If you have liver problems such as cirrhosis of the liver, Crestor may not be a good drug for you.  For this reason, your doctor will test your liver's function to evaluate if Crestor therapy is appropriate for you. 

It is recommended that liver function tests be performed before someone begins Crestor therapy and at 12 weeks following both the initiation of therapy and any elevation of dose, and periodically (e.g., semiannually) thereafter.

This is done with as simple blood test.  In most cases, people with vastly elevated liver enzymes should stop taking Crestor or other statin drugs.

The normal starting dose of Crestor is 10mg per day.  The maximum dose of Crestor is 40 mg per day.

Crestor therapy usually starts with a 10mg dose.  Sometimes the doctor willstart with a 20mg dose.  The 40mg dose is reserved for people who are on 20mg but still are not meeting their cholesterol goals.

Crestor's labeling contains comparisons to Lipitor.  (Crestor label shows that it is slightly more effective than Lipitor in reducing LDL's).  Crestor increases HDL's very nicely.

Crestor Safety, Crestor Starting Dose(s)

Crestor has been extensively tested by the FDA and determined to be a safe and effective product.  Few products on the market today have experienced the level of scrutiny that the FDA exposed Crestor to.

Some people claim that Crestor has dangerous side effects such as proteinuria (protein in the urine) and rhabdomyolysis, (a dangerous condition where the muscles break down and release toxic chemicals into the bloodstream that hurt the kidneys).

The maximum starting dose of Crestor is 20mg per day for tough cases where aggressive cholesterol lowering tactics are required (such as for diabetics or people who have had heart attacks).

As long as your doctor is following the manufacturer's directions, you should have nothing to worry about. 

If your doctor disregards the manufacturer's directions, and he gives you higher than recommended doses of Crestor you are more likely to run into problems.

Most people taking Crestor reach their LDL cholesterol goals by taking the starting dose of 10 mg. 

Crestor's Special Pricing:

All doses of Crestor cost the same price.  The 10 mg dose costs the same price as the 40 mg dose.  For this reason, the insurance companies like Crestor. 

Crestor Information On The Internet:

Crestor Price Comparison: information that doctor's use to learn about how to prescribe Crestor; prescribing information, formulary information, safety information, very technical, don't get scared when you come to the section on warnings and side effects.

Official Crestor Prescribing Information (Package Insert); dose, mechanism of action, side effects, precautions, warnings; patient information; very technical, don't get scared when you come to the section on warnings and side effects.
Editor's Note: This page appears as a pop-up.  If you have your computer set to block pop-up's you can not see this page.  If you want to see this page, turn off your pop-up blocker.

Crestor Prescribing Information; Source B;  ( from Rx; the #1 drug information site on the internet) ; prescribing information; dose, mechanism of action, side effects, precautions, patient information.  Use this site if you are unable to see the official Crestor website.  This information is very technical, don't get scared when you come to the section on warnings and side effects.

Crestor Approval Letter; 8/12/03;
(PDF File; Adobe required); this is the letter that FDA sent to AstraZeneca indicating that Crestor had satisfied FDA safety and efficacy requirements and that Crestor could be marketed in the USA pending appropriate labeling.

Crestor Scientific Papers ( from the National Library of medicine) automated Medline search; a listing of scientific papers in abstract form regarding Crestor.

Crestor Patient Information similar to the flyer that people taking Crestor will get from the drugstore when they fill their Crestor  prescription.

Crestor News, Safety Controversy, Pertinent Press Releases:

  • Crestor News (from Google) recently published news regarding Crestor; sorted by date/time; updated in real time.

  • Anti-Crestor Press Release; Health Activist organization, Public Citizen 6/26/04 explains why it thinks Crestor should be taken off of the market.

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